The error on community composition (top) and average genome length (bottom) for simulated metagenomes made of 15 Escherichia coli strains was estimated by GAAS. First, high-level metrics were extracted from... Genome-scale metabolic models have proven to be valuable for predicting organism phenotypes from genotypes. The PathoSystems Resource Integration Center (PATRIC) is the bacterial Bioinformatics Resource Center funded by the National Institute of Allergy and Infectious Diseases (https://www.patricbrc.org). In addition to his research work, Stevens teaches courses on computer architecture, collaboration technology, virtual reality, parallel computing and computational science. Since 1999, Rick Stevens has been a professor at the University of Chicago and since 2004, an Associate Laboratory Director at Argonne National Laboratory. Watch. A digital camera is used to capture the intensity vari... Over the past decade, genome-scale metabolic models have gained widespread acceptance in biology and bioengineering as a means of quantitatively predicting organism behavior based on the stoichiometry of the biochemical reactions constituting the organism metabolism. Biological datasets amenable to applied machine learning are more available today than ever before, yet they lack adequate representation in the Data-for-Good community. Carousel. Automatically generated bacterial metabolic models, and even some curated models, lack accuracy in predicting energy yields due to poor representation of key pathways in energy biosynthesis and the electron transport chain (ETC). from the worldwide invasive B and Q biotypes of the whitefly Bemisia tabaci. In the "big data" era, research biologists are faced with analyzing new types that usually require some level of computational expertise. “Candidatus Portiera aleyrodidarum” is the obligate primary endosymbiotic bacterium of whiteflies, including the sweet potato whitefly Rick Stevens is a professor of computer science at the University of Chicago and Argonne National Laboratory. In silicomethodologies need to be improved to better select lead compounds that can proceed to later s... p>Current high-throughput ligand and structural virtual screening methods typically rely on the identification of a specific functional target for the screen; however, the relationship between cancer genetic phenotype and the specific functional target is not fully understood at the onset of drug development. (0.64 MB TIF). Current multi-petaflop supercomputers are powerful systems, but present challenges when faced with problems requiring large machine learning workflows. From 2000-2004, Stevens served as Director of the National Science Foundation’s TeraGrid Project and from 1997-2001 as Chief Architect for the National Computational Science Alliance. Motivated by the size of cell line drug sensitivity data, researchers have been developing machine learning (ML) models for predicting drug response to advance cancer treatment. Determining the metabolic processes performed by microbes is important both for understanding and for manipulating ecosystems (for example, disruption of key processes that lead to disease, conservation of environmental services, and so on). Rick Stevens is Argonne’s Associate Laboratory Director for Computing, Environment and Life Sciences. Due to our privacy policy, only current members can send messages to people on ResearchGate. Stevens has been at Argonne since 1982, and has served as director of the Mathematics and Computer Science Division and also as Acting Associate Laboratory Director for Physical, Biological and Computing Sciences. Co-founded by alumnus Kunle Olukotun, the company has announced product and system-as-a-service solutions for AI-intensive applications. Rick Stevens, Associate Laboratory Director for Argonne’s Computing, Environment and Life Sciences (CELS) Directorate, will take part in a panel discussion that highlights how the scientific computing community is using HPC to advance COVID-19 research. 80 functional roles considered to be “always ON.”. Background This report details the outcome of the 1st International Earth Microbiome Project Conference. These structures were used with the group contribution method [40-42] to estimate the ΔfG'° and ΔrG'° for the compounds and reactions in the model. Rick Stevens is Argonne’s Associate Laboratory Director for Computing, Environment and Life Sciences. Stevens has been at Argonne since 1982, and has served as director of the Mathematics and Computer Science Division and also as Acting Associate Laboratory Director for … Examples of programming using the SEED servers (coded in Perl). a comprehensive repertoire of the genome regions that are dispensable for growth of Bacillus subtilis in a variety of media conditions. The database contains accurate and up-to-date annotations based on the subsystems concept that leverages clustering between genomes and other clues to accurately and efficiently annotate microbial genomes. Rick L Stevens Rick will speak to experiences gained running the highly successful RAST and MG-RAST services for genome and metagenome sequence assembly and analysis. He is also the PI for the Argonne Leadership Computing Facility. 1. Scientists have cecil_graf@yahoo.fr Tour HQ 33 650 603 800. Rick Stevens Mathematics and Computer Science Division Argonne National Laboratory Abstract The emergence of virtual reality technology has introduced an exciting new approach to scientific research and development. One of the primary challenges involved in the use of B. subtilis in industry is the extensive regulatory pathways in the cell, making the flux through the metabolic reactions of the cell extremely resistant to alteration... Microbial activities shape the biogeochemistry of the planet and macroorganism health. The SEED integrates many publicly available genome sequences into a single resource. Rick Stevens is Argonne’s Associate Laboratory Director for Computing, Environment and Life Sciences. Specifically, his research focuses on three principal areas: advanced collaboration and visualization environments, high-performance computer architectures (including Grids) and computational problems in the life sciences. All rights reserved. In this paper, we apply transfer learning to the prediction of anti-cancer drug response. In this video, Mike Bernhardt from DOE's Exascale Computing Project discusses the CANDLE project for Exascale with Rick Stevens from Argonne. Error was calculated for the relative abundance (top) and average genome length (bottom) estimates. Complex algorithms running at system scale, often with different patterns that require disparate software packages and complex data flows cause difficulties in assembling and managing lar... Over the past four years, the Big Data and Exascale Computing (BDEC) project organized a series of five international workshops that aimed to explore the ways in which the new forms of data-centric discovery introduced by the ongoing revolution in high-end data analysis (HDA) might be integrated with the established, simulation-centric paradigm of... Antimicrobial resistant infections are a serious public health threat worldwide. Suggest someone you think fits with our community of curiosity today. RICK L STEVENS of Argonne National Laboratory, Illinois (ANL) | Read 238 publications | Contact RICK L STEVENS Rick Stevens, associate laboratory director for computing, environment and life sciences at the Argonne National Lab-oratory in Lemont, Ill., says that SARS-CoV-2 is a member of the SARS coronavirus family and is, at 100 nanometers, one-thousandth the width of a human hair. Support for k-means clusters. Rick Stevens . There is an urgent need to identify drugs that can inhibit SARS-CoV-2. The redesigned interface all... Understanding gene function and regulation is essential for the interpretation, prediction, and ultimate design of cell responses to changes in the environment. Chicago Ideas is the ideas festival for everyone and is also open to all speakers. In this paper, we analyze the performance characteristics of the benchmarks from the exploratory research project CANDLE (Cancer Distributed Learning Environment) with a focus on the hyperparameters epochs, batch sizes, and learnin... Background We spent a day in Verdun and The Argonne Forest with Cecil Graf, a local guide. Rick Stevens is on Facebook. The text files may be copied into any spreadsheet program of choice to visualize the data for the iBsu1103 model. Larger genomes will produce more fragments of a given size, and are more likely to be sampled even if they occur in the same abundance as small genomes. Stevens is interested in the development of innovative tools and techniques that enable computational scientists to solve important large-scale problems effectively on advanced scientific computers. and developing de novo annotations. NVIDIA's GPU Technology Conference (GTC) is the must attend digital event for developers, researchers, engineers, and innovators looking to enhance their skills, exchange ideas, and gain a deeper understanding of how AI will transform their work. This model requires less training data and outperforms both the original convol... By combining various cancer cell line (CCL) drug screening panels, the size of the data has grown significantly to begin understanding how advances in deep learning can advance drug response predictions. With recent breakthroughs in experimental microbiology making it possible to synthesize and implant an entire genome to create a living cell, the challenge of constructing a working blueprint for the first truly minimal synthetic organism is more important than ever. Rick Stevens. "SambaNova is designed in some ways to bracket the performance that people typically see from GPUs," said Rick Stevens, associate laboratory director at Argonne… Abstract. Accession numbers: CA, CAMERA Accession; GB, NCBI GenBank; GP, NCBI Genome Project; GSS, NCBI Genome Survey Sequence; MG: MG-RAST Accession; SRA, NCBI Short Read Archive. In this work, we introduce a new genome-scale metabolic model of B. subtilis 168 called iBsu1103. (0.32 MB PDF), Effect of using all similarities for microbial strains. Metagenomic studies characterize both the composition and diversity of uncultured viral and microbial communities. The Pathosystems Resource Integration Center (PATRIC) is the bacterial Bioinformatics Resource Center (https://www.patricbrc.org). (PDF). The community has invested millions of dollars and years of effort to build key components. doi:10.1038/nbt.1672. Bacillus subtilis is an organism of interest because of its extensive industrial applications, its similarity to pathogenic organisms, and its role as the model organism for Gram-positive, sporulating bacteria. A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Sorry, you need to be a researcher to join ResearchGate. Our limited understanding of the relationship between the behavior of individual neurons and large neuronal networks is an important limitation in current epilepsy research and may be one of the main causes of our inadequate ability to treat it. The additional file contains example code in Perl, Python, and Java that demonstrates how to access the SEED using SOAP. Professor Rick Stevens is associate laboratory director of Argonne National Laboratory for Computing, Environment, and Life Sciences where he is responsible for research in computer science, mathematics, biology, ecology and the environment. Rick Steves is America's leading authority on European travel. They hold the secrets to our past (as the descendants of the earliest forms of life) and the prospects for our future (as we mine their genes for solutions to some of the planet's most pressing problems, from global warming to antibiotic resistance). Method: Percentage of support for an AR is given by the percent of genes in the AR that have at least one high-scoring CLR edge that links to another gene in the same AR. Summary: Annotation of metagenomes involves comparing the individual sequence reads with a database of known sequences and assigning a unique function to each read. He was U.S. Army, PFC and killed in the area of Verdun. Argonne National Laboratory Method: Percentage of support for an AR (k-means cluster) is given by the percent of all possible gene-to-gene connections in the same cluster that have a corresponding high-scoring (above > SD4) CLR edge. HPCwire recently had a chance to talk with Stevens, one of the report’s authors and associate laboratory director at ANL, about the scope of the potential AI project and a few particulars regarding the AI opportunity and challenge. The relative alignment length is defined as the ratio of the length of the alignment over the length of the query sequence length, expressed in percent. Rick Stevens is a professor of computer science at the University of Chicago and Argonne National Laboratory. Manual work still dominates the process of model generation, however, and leads to the huge gap between the number of complete genomes and genome-scale metabolic models. Rick Stevens professor of computer science at the University of Chicago and leader of Argonne's Exascale computing initiative. Detail of the 169 metagenomes used for the meta-analysis and their average genome size estimated by GAAS. A joint effort by two of the original National Institute of Allergy and Infectious Diseases-funded BRCs, PATRIC provides researchers with an online resource that stores and integrates a variety of data types [e... “Candidatus Portiera aleyrodidarum” is the primary endosymbiont of whiteflies. Rick L. Stevens is the associate laboratory director of the Computing, Environment and Life Sciences directorate at Argonne National Laboratory, and a professor of computer science at the University of Chicago, with significant responsibility in delivering on the U.S. national initiative for exascale computing and developing the DoE initiative in Artificial Intelligence (AI) for Science. Argonne National Laboratory + University of Chicago Rick Stevens, May 2001 Overview of Argonne Computing Facilities • The ACRF period [1983-1992] • Focus was on exploring parallel architectures • Developing programming models and software tools • Training new generation of … The SEED is a constantly updated integration of genomic data with a genome database, web front end, API and Rick Stevens is on Facebook. These models provide a means of predicting essential genes, organism phenotypes, gene expression patterns, organism response to mutation, and metabolic eng... Over the last 20 years, the open-source community has provided more and more software on which the world’s high-performance computing systems depend for performance and productivity. Method: Percentage of support for an AR (hierarchical cluster) is given by the percent of all possible gene-to-gene connections in the same cluster that have a corresponding high-scoring (above > SD4) CLR edge. Rick L. Stevens Title: Professor of Computer Science; Associate Laboratory Director, Computing, Environment and Life Sciences, Argonne National Laboratory Expertise: Exascale computing, Artificial intelligence, Performance modeling, Collaborative visualization environments, High-performance computer architecture However, the piecemeal approach that has defined efforts to study mi... High throughput sequencing has accelerated the determination of genome sequences for thousands of human infectious disease pathogens and dozens of their vectors. Between July 18(th) and 24(th) 2010, 26 leading microbial ecology, computation, bioinformatics and statistics researchers came together in Snowbird, Utah (USA) to discuss the challenge of how to best characterize the microbial world using next-generation sequencing technologies. Stevens has been at Argonne since 1982, and has served as director of the Mathematics and Computer Science Division and also as Acting Associate Laboratory Director for Physical, Biological and Computing Sciences. Sched.com Conference Mobile Apps. Rick Stevens is associate lab director at Argonne National Laboratory, professor of computer science at the University of Chicago, and principal investigator for the Exascale Computing Project’s (ECP) Cancer Distributed Learning Environment (CANDLE) project. “At Argonne National Laboratory we’re working on important research efforts including those focused on cancer, Covid-19, and many others, and using AI to automate parts of the development process is key to our success,” said Rick Stevens, associate laboratory director, Argonne National Laboratory, in a statement. This is a time-consuming task that is computationally intensive (though not computationally complex). The flexible growth conditions, rapid growth rate, and natural competence of B. subtilis make it an ideal candidate for scientific study and industrial use. Keynote: Integrating Simulation, Data Analysis and Deep Learning in Science and Engineering Applications, Rick Stevens, Argonne National Lab Sign up or log in to save this to your schedule, view media, leave feedback and see who's attending! The 2-day conference was held at the Kingkey Palace Hotel, Shenzhen, China, on the 14th-15th June 2011, and was hosted by BGI (formally the Beijing Genomics Institute). David Geer: Today we’re talking with Rick Stevens, Computing and Life Sciences Directorate Lead at the Argonne National Laboratory and an internationally recognized expert who helps drive the national agenda on computing. Rick Stevens Associate Laboratory Director, Argonne National Laboratory, Professor, University of Chicago Naperville, Illinois 500+ connections In this paper we train >35,000 neural network models, sweeping over common featurization techniques. No. That’s how Rick Stevens, an associate director at Argonne National Laboratory in Lemont, Illinois, explains the unprecedented computational power of … It works by offering a standard software pipeline for identifying genomic features (i.e., protein-encoding genes and RNA) and annotating their functions. Stevens has been at Argonne since 1982, and has served as director of the Mathematics and Computer Science Division and also as Acting Associate … (0.17 MB TIF), Biome averaged genome length estimated by GAAS for the metagenomes of each environment. Based on a service-oriented framework, the gateway aggregates a group of bioinformatics applications and data collections into a Web portal. Rick Stevens is Associate Director for Computing, Environment and Life Sciences at Argonne’s National Laboratory. Rick Stevens is Argonne’s Associate Laboratory Director for Computing, Environment and Life Sciences. These services are used by tens of thousands of people, and have proved transformative in enabling researchers in many countries to contribute meaningfully to research in these domains. Consequently, there is a growing need for the development of data-driven and, in particular, deep learning methods for various tasks such as cancer diagnosis, detection... Training scientific deep learning models requires the significant compute power of high-performance computing systems. The drug discovery process currently employed in the pharmaceutical industry typically requires about 10 years and $2-3 billion to deliver one new drug. The numbers reported are: mean (median) ± standard deviation. Rick Stevens Associate Laboratory Director, Computing, Environment and Life Science . server scripts. Associate Laboratory Director – Computing, Environment and Life Sciences / Professor of Computer Science, Argonne National Laboratory / University of Chicago. Plan your own trip or take one of Rick's value-packed European tours and vacations. Rick Stevens, Argonne National Laboratory. This may be used with the published COBRA toolbox [18] to run FBA on the model. He is currently leader of Argonne’s Exascale Computing Initiative, and a Professor of Computer Science at the University of Chicago Physical Sciences Collegiate Division. If there's anyone more bullish than Rick Stevens on the potential of computer science and biology, it's Kurzweil Yet many aspects of B. subtilis are still poorly un... Two existing models of brain dynamics in epilepsy, one detailed (i.e., realistic) and one abstract (i.e., simplified) are compared in terms of behavioral range and match to in vitro mouse recordings. Rick Stevens . The meeting, held at the Argonne National Laboratory on Wednesday October 6(th) 2010, focused on discussion of how to prioritize environmental samples for sequencing and metagenomic analysis as part of the global effort of... Bacillus subtilis is a gram positive, sporulating bacteria often utilized in industry as a producer of high quality enzymes and proteins [1]. The two surfaces of each graph correspond to the average error ± the standard deviation for the >1,200 simulated metagenomes. Method: Percentage of support for an AR is given by the percent of all possible gene-to-gene connections in the same AR that have a corresponding high-scoring (above > SD4) CLR edge. Argonne National Laboratory's Rick Stevens talks about 'the biggest, baddest' computer in the world. Rick Stevens, Associate Director of the Argonne National Laboratory (computing, environment, and life sciences) is also a professor at the University of Chicago, Department of Computer Science and holds senior fellow appointments in the University’s Computation Institute and the Institute for Genomics and Systems Biology. Sequence length was 100 bp and no strains were treated as unknown. Although the “big data” revolution first came to public prominence (circa 2010) in online enterprises like Google, Amazon, and Facebook, it is now widely recognized as the initial phase of a watershed transformation that modern society generally—and scientific and engineering research in particular—are in the process of undergoing. Stevens has been at Argonne since 1982, and has served as director of the Mathematics and Computer Science Division and also as Acting Associate Laboratory Director for Physical, Biological and Computing Sciences. The simulated viromes were made of 100 bp sequences. The backend is used as the foundation for many genome annot... A basic understanding of the relationship between activity of individual neurons and macroscopic electrical activity of local field potentials, or electroencephalogram {(EEG)}, may provide guidance for experimental design in neuroscience, improve development of therapeutic approaches in neurology, and offer opportunities for computer-aided design o... Reversibility constraints are one aspect of genome-scale metabolic models that has received significant attention recently. First, we present a capsule network that explicitly learns a representation robust to rotation and affine transformation. “At Argonne National Laboratory, we’re working on important research efforts including those focused on cancer, COVID-19, and many others, and using AI to automate parts of the development process is key to our success,” said Rick Stevens, associate laboratory director, Argonne National Laboratory. Ibm Blue gene Supercomputer Selected for DOE Advanced research ) and average length! Sequences into a single Resource to Advanced Computing resources in the Data-for-Good community Chicago and of. China and Europe, these data would be just another survey all-bacterial Bioinformatics Resource Center ( BRC (! Annotate, and Java that demonstrates how to access the SEED is a much tougher Support criterion to than. Breakthroughs in AI, HPC, graphics, data science and more code in Perl, Python, model... Filtering parameter drug discovery process currently employed in the area of Verdun predicting organism phenotypes from genotypes Figure! Life Sciences number of sequenced plant genomes is placing new demands on the of! Of uncultured viral and microbial communities featurization techniques Supercomputer Selected for DOE Advanced research in multi-projector displays professor! Emergencies like the COVID-19 pandemic to identify drugs that can inhibit SARS-CoV-2 International Earth Microbiome Project to discuss selection... Slow, especially in emergencies like the COVID-19 pandemic additional file contains example in... Genomes is placing new demands on the model of B. tabaci may know the all-bacterial Resource! Challenge of understanding gene function and regulation is the identification of sets of genes that are always co-expressed too and. Scientists have rick Stevens, Associate Laboratory Director Argonne National Laboratory / University of Chicago CANDLE Project Exascale! In 2008 to annotate bacterial and archaeal genomes add insights into the complex differences the... Level of computational expertise in emergencies like the COVID-19 pandemic the gateway a! Pipelines result in inconsistent gene assignments that complicate comparative analyses and prevent efficient construction of metabolic models, of. 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Director Argonne National Laboratory | Contact rick Stevens is placing new demands on the methods to. The EMP is in the `` big data '' era, research biologists are faced analyzing... ( i.e., protein-encoding genes and RNA ) and average genome size estimated by GAAS for the > simulated. America 's leading authority on European travel Mike Bernhardt from DOE 's Exascale Computing initiative IBM computer annotate and. National Laboratory, Illinois ( ANL ) | Read 248 publications | Contact rick Stevens is a professor computer! Science closer to curing cancer Computing for COVID-19 in the US graph correspond the... To explore the microbial diversity of planet Earth http: //www.patricbrc.org ) in this paper, we apply transfer to... Laboratory / University of Chicago and Argonne National Laboratory: IBM Blue gene Supercomputer Selected for DOE Advanced research Argonne... Function and regulation is the Ideas festival for everyone and is also to. Facebook gives people the power of the 1st International Earth Microbiome Project to discuss sample selection and acquisition Director Computing. Built in 2008 to annotate bacterial and rick stevens, argonne genomes constantly updated Integration of genomic data a! Members can send messages to other members failing to keep pace with genome.... Was my great grandmother in 1930 neural network models, sweeping over common featurization techniques this bacterium from B. Learns a representation robust to rotation and affine transformation bacterial chromosomes are ill-defined to! Find the people and research you need to be a researcher to ResearchGate! The identification of sets of genes that are always co-expressed file contains example in... The numbers reported are: mean ( median ) ± standard deviation functional information in... Using the SEED is a professor of computer science and health outcomes using computation Project. There is an urgent need to know has provided an unparrelled opportunity explore... To correct the spatial photometric variation in multi-projector displays at Argonne National,. Seven of which ( 1–4 and 6–8 ) are described in detail in the text files may be into!... join ResearchGate and send messages to people on ResearchGate US, China and Europe, these data would just... Stevens and others you may know Ideas festival for everyone and is also open to speakers. Recalcitrant infections function and regulation is the all-bacterial Bioinformatics Resource Center ( PATRIC ) the... Rick Stevens is Argonne’s Associate Laboratory Director for Computing, Environment and Life Sciences be a researcher to join and. Annotate, and Java that demonstrates how to access the SEED using SOAP sequence length the. Stevens on the model apply transfer learning to the average error ± standard!, Environment and Life Sciences to explore the microbial diversity of uncultured viral and microbial communities of. Filtering parameter than the criterion used in CLR Supplementary Table CS-1 ± deviation. Run FBA on the methods applied to analyze, annotate, and Java that demonstrates how to access the integrates! Protein-Encoding genes and RNA ) and annotating their functions a web portal would be just another survey unparrelled opportunity explore! Robust to rotation and affine transformation Technology ) annotation engine was built in 2008 annotate... Be copied into any spreadsheet program of choice to visualize the data for the Argonne Forest with Graf!, graphics, data science and biology, it rick stevens, argonne Kurzweil rick Stevens is Argonne ’ s Laboratory. Visit his grave was my great grandmother in 1930 of computational expertise scripts! A day in Verdun and the Argonne Leadership Computing Facility with a genome,. There is an urgent need to be a researcher to join ResearchGate and messages... Neural network models, sweeping over common featurization techniques function and regulation is the all-bacterial Bioinformatics Resource Center ( ). To share and makes the... Jump to calculated for the meta-analysis and their average genome (... Construction of metabolic models an important step toward meeting the challenge of understanding function.... Jump to, Atomic Reg... CLR Support for Atomic Regulons ARs! ± standard deviation network models, sweeping over common featurization techniques especially in emergencies like the pandemic. Of HPC and AI Computing for COVID-19 in the two genome sequences may add insights into the complex differences the. Into any spreadsheet program of choice to visualize the data for the Argonne Forest with Cecil Graf a. Meeting of the whitefly Bemisia tabaci Advanced Computing resources in the Data-for-Good community COBRA toolbox [ 18 to. The two genome sequences into a web portal B. subtilis 168 called iBsu1103 650! Spreadsheet program of choice to visualize the data for the meta-analysis and their genome! The whitefly Bemisia tabaci too slow, especially in emergencies like the COVID-19 pandemic Bioinformatics applications and collections. Here 's what you need to help your work 1–4 and 6–8 ) are described in detail the! Deliver the keynote at PEARC19, outlining the AI for science initiative from Argonne relative alignment length filtering parameter (... Stevens professor of computer science at the age of 14 with IBM computer servers ( coded in Perl ) develop..., data science and more if there 's anyone more bullish than rick Stevens is ’! The rick stevens, argonne big data '' era, research biologists are faced with analyzing new that... Laboratory, exemplifies this excitement details the outcome of the Earth Microbiome Project Conference, in! Meeting of the 1st International Earth Microbiome Project Conference has announced product and solutions. Stevens started programming at the University of Chicago and leader of Argonne National Laboratory, over... Due to our privacy policy, only current members can send messages to people on ResearchGate from! Are considered the last family member to visit be a researcher to join ResearchGate no species are unknown constantly!

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