The silymarin exerts membrane-stabilizing and antioxidant activity, it promotes hepatocyte regeneration; furthermore it reduces the inflammatory reaction, and inhibits the fibrogenesis in the liver. 140mg-capsule: 1 capsule/time x 3 times a day. Phytosome technology improves the bioavailability of silybin as it is complexed with phosphatidylcholine. Common side effects of Silymarin : Abdominal bloating, diarrhea, flatulence, loss of appetite, nausea and stomach upset. Click here for full details on all the markets covered. These results have been established by experimental and clinical trials. MIMS products are highly valued and utilised widely across Australia by healthcare professionals in public and private acute care, primary care, aged care, community services – just to name a few. The dosage has not been established in pediatric patients. What is the dose of Legalon® (Silymarin) for an adult? 140 Tablet:Role of Silymarin- Powerful antioxidant; Used to protect liver cells (and other cells in the body and brain) from toxins. There were no side effects from silymarin.4 Silymarin may intensify the effects of drugs that decrease blood sugar levels (hypoglycemic drugs). Schauss AG, Somfai-Relle S, Financsek I, et al. Brief stomach upset and mild allergies, but no serious side effects, have been reported. Silymarin promotes liver cell protein synthesis and decreases the oxidation of glutathione. 70mg-capsule: 2 capsule/time x 3 times a day. The combination of silybin and phosphatidylcholine in Liverprime is three times better absorbed than plain Silymarin. In people with liver disease, the typical dosage was higher, around 1.3 g/day of the standardized for 6 – 8 weeks (divided into 3 doses during the day). What is the dose of Legalon® (Silymarin) for a child? Search drug, interactions and image information in China, Hong Kong, Taiwan, Malaysia, Singapore, Philippines, Vietnam, Thailand, Indonesia, India & USA Subjects received 140 mg silymarin three times a day for 41 months. It can cause nausea, vomiting, and diarrhea or constipation. Silymarin is a fruit extract from the plant milk thistle that is claimed to be a free radical scavenger and to have hepatoprotectant properties; it has been used in various liver … 1. The IV median lethal dose in rodents was suggested to be around 4 g/kg. The recommended dose is 140 mg 2-3 timesday. The typical silymarin dosage used in most studies was ~420 mg/day divided into 2 or 3 doses. The reduced death rate among those taking silymarin was most pronounced in the alcoholic cirrhosis subgroup. It may be unsafe for your child. In dogs given oral citicoline 1.5 g/kg daily for 6 months, no biochemical, neurological, or histological toxicity was found.1. 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