polygonum multiflorum liver damage

Polygonum multiflorum (witch hazel) is often recommended for topical use but in traditional Chinese medicine it is also used orally. One additional reference was identified while searching reference lists of the included papers. (HSW), we provide a systematic review of case reports and case series about liver damage associated with HSW. Song, “Correlation analysis of drug-induced liver injury caused by, Y. Wang, “Clinical research of drug-induced liver injury caused by, X. Zhang, X. C. Ding, Y. Yang, P. Zhang, and F. F. Wu, “Clinical analysis of 6 patients with liver diease induced, M. Leng, “One case of acute severe liver injury caused by conventional dose Polygonum multiflorum,”, J. Q. Sheng, “Familial acute liver injury caused by, Q. H. Ye, “One case of acute toxic liver disease caused by, W. Huang, Y. N. Zhang, and R. Sun, “Experimental study on the “Dose-Time-Toxicity” relationship of acute hepatotoxicity induced by different components from, J. Yu, J. Xie, R.-H. Zhao, S.-Q. Clipboard, Search History, and several other advanced features are temporarily unavailable. HSW is popular in many countries, especially in China. Evid Based Complement Alternat Med. The references of relevant reviews and the included literatures were checked for possible identification of additional studies. The study showed that high dose P. multiflorum water extract had hepatotoxicity, and the degree of liver damage was increased with the increase of dose. Please enable it to take advantage of the complete set of features! The news article reporting the death of the student did not reveal if he suffered from a known liver condition. Sun, “One case of severe liver damage caused by Chinese drugs for invigoration,”, J. Y. Yang, “One case of liver damage caused by, G. J.-H. Park, S. P. Mann, and M. C. Ngu, “Acute hepatitis induced by Shou-Wu-Pian, a herbal product derived from Polygonum multiflorum,”, Z. H. Li, D. M. Gai, and X. R. Zhuang, “Hepatitis attributed to, D. M. Fan and Z. L. Zhou, “One case of liver damage caused by, F. X. Li, “One case of liver injury caused by Shou-Wu-Wan,”, W. F. Zhang, “One case of liver injury caused by Huo-Li-Su,”, J. H. Niu, “One case of severe liver damage caused by Shou-Wu-Pian,”, M. H. He and X. J. Zhen, “Two cases of acute liver damage caused by, P. P.-H. As a Chinese herb, it was recorded most early in “Kaibao Bencao” published by the imperial court of the Song Dynasty (973-974 A.D.) [1]. 2019. Gao X., Hu Y.-J., Fu L.-C. However, although PM extracts are generally considered to be relatively safe, PM extracts may still show hepatotoxicity. eCollection 2020. Polygonum Multiflorum for Liver Health Animal research shows that P. multiflorum reduces fat deposits inside the liver. In 72 cases of case reports, patients ranged in age from 5 to 78 years, with a median of 36.5. 2007;32(4):323–326. The root of Reynoutria multiflora (Thunb.) HSW can cause different degrees of liver injury, even need of liver transplantation (2/450), and death (6/450). Chinese Journal of Experimental Traditional Medical Formulae. For the 28 cases who consumed Chinese patent medicines in case reports, 17 (17/28, 60.7%) cases are in accordance with the recommended dosage and the remaining are unknown. Mechanism research of stilbene glucoside from Polygonum multiflovum thunb on hyperlipemia. The HSW forms of case reports are shown in Table 4; in terms of usage, all involved Chinese patent medicines are of oral formulation; the types of HSW decoction pieces used included tea, liquor, powder, and decoction. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. In case reports, the length of 64 patients’ hospitalization ranged from 6 to 120 d, with a median of 29.5 (Table 6).  |  A handful of patients were found with abdominal distension, abdominal pain, diarrhea, rash, pruritus, and other symptoms. eCollection 2020 May 12. Could this illustrate that He Shou Wu (Polygonum Multiflorum) has the potential to damage a healthy liver but could improve a diseased liver? Some clinical trials of HSW that reported liver damage were excluded for reasons originally given by Lao et al., specifically that they were too small to provide convincing evidence of rare complications [16]. To summarize the characteristics and analysis of relevant factors and to give references for prevention and further study of liver damage associated with Polygonum multiflorum Thunb. If fatigue, anorexia, nausea, yellowing of skin and sclera, yellow urine, and other symptoms appear after medication, patients should be alerted to the occurrence of liver damage and promptly stop the medicine and treatment. Results. The two forms have different properties: the raw HSW is used for detoxification, eliminating carbuncle, preventing malaria, and relaxing bowel, whereas the processed HSW is used for nourishing liver and kidney, supplementing essence and blood, blackening hair, strengthening bones and muscles, eliminating dampness, and reducing lipid [2]. USA.gov. Zhou M, Hu N, Liu M, Deng Y, He L, Guo C, Zhao X, Li Y. Biomed Res Int. : a systematic review of case reports and case series. Q. T. Chen, L. H. Zhuo, W. Xu, Z. H. Huang, and X. H. Qiu, “Content changes of 5 components in, X. Han, C. A. Wu, W. Wang, S. Liu, and L. Y. Wang, “Mechanism research of stilbene glucoside from, X. Gao, Y.-J. COVID-19 is an emerging, rapidly evolving situation. This study aimed to identify the genetic basis of susceptibility to PM‐drug‐induced liver … According to case reports and case series, most of the patients had been hospitalized with jaundice, fatigue, anorexia, and yellow or tawny urine. But, B. Tomlinson, and K.-L. Lee, “Hepatitis related to the Chinese medicine Shou-Wu-Pian manufactured from, F. Liu and Z. Li, “Analysis of 7 cases of drug-induced liver injury by, X. X. Yang, N. Jiang, and J. M. Lin, “Clinical analysis of 13 patients with liver diease induced. The liver damage in most patients is reversible, after discontinuation of HSW products, and active treatment can restore liver function, but there are also a small number of patients with liver failure and even death. Objective. Clinical trials, reviews, commentaries, and other nonrelated literatures were excluded. Based on the above information we know that HSW associated with liver injury can occur at any age group and with no gender orientation. He Shou Wu benefits the health of your kidney and liver and supports the … Legend says that fo-ti was discovered by a Chinese man, Mr. The length of hospitalization of case reports. 2015, Article ID 459749, 9 pages, 2015. https://doi.org/10.1155/2015/459749, 1Tianjin University of Traditional Chinese Medicine, 88 Yuquan Road, Tianjin 300193, China, 2Center for Drug Reevaluation, State Food and Drug Administration, Xicheng, Beijing 100045, China, 3Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, 816 Zhenli Road, Tianjin 300150, China, 4Dongzhimen Hospital, Beijing University of Chinese Medicine, Dongcheng, Beijing 100007, China, 5Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China. The review was supported financially by Tianjin University Innovation Team Training Program (TD12-5032). 2019 May 10;235:472-480. doi: 10.1016/j.jep.2018.12.007. It is known as tuber fleeceflower and Chinese … Case reports and case series are included in the review if they reported factual data on liver damage related to HSW. After screening, articles were read in full and extracted by two independent reviewers (Xiang Lei and Jing Chen). In case series, seven articles reported 53 (53/138, 38.4%) cases with liver damage related to HSW many times [17, 21, 27, 29–31]. Huang Y, Zhao X, Zhang ZT, Chen SS, Li SS, Shi Z, Jing J, Huang A, Guo YM, Bai ZF, Zou ZS, Xiao XH, Wang JB, Niu M. Front Med (Lausanne). There are many signs and symptoms of liver disease. 2009;9(20):3968–3982. Wei J, Chen J, Fu L, Han L, Gao X, Sarhene M, Hu L, Zhang Y, Fan G. J Ethnopharmacol. The mechanism of HSW induced liver damage is still unclear and mainly toxic substances are also an uncertainty [15, 36]; even few animal experiments did not find hepatotoxicity of HSW [37, 38]. With the wide application, liver damage associated with HSW has been reported in China, Korea, Japan, Britain, Italy, Australia, and other countries [14, 15]. Liver damage associated with HSW is reversible, and, after active treatment, the majority can be cured. Xiang Lei and Jing Chen contributed equally to this work. Epub 2017 Jan 24. In 450 cases, 224 (49.78%) were male and 226 (50.22%) were female. To summarize the characteristics and analysis of relevant factors and to give references for prevention and further study of liver damage associated with Polygonum multiflorum Thunb. To determine the main clinical and pathological characteristics of liver … Epub 2018 Dec 6. (PM) induced DILI (PM-DILI) have received much attention This study aimed to … Although only 25 cases of case reports have the HSW dosage information, 14 cases exceed maximum dosages (12 g/d). Lei X, Chen J, Ren J, et al. We are committed to sharing findings related to COVID-19 as quickly as possible. : Polygonum multiflorum Thunb., HSW) is a distinguished herb that has been popularly used in traditional Chinese medicine (TCM). P. multiflorum and its extracts should be considered hepatotoxic; however, the plant is widely used in traditional Chinese medicine and Ayurvedic medicine for its rejuvenating and toning properties, to increase liver and kidney function, for treatment of cognitive di… I believe these issues mainly come from two reasons: 1) inappropriate harvest of the herb where the … 10.1155/2015/459749 … Methods. Evid Based Complement Alternat Med. The case series that reported the average length of hospitalization was about four weeks [18, 21, 23, 28–31]. Li YX, Gong XH, Liu MC, Peng C, Li P, Wang YT. Evid Based Complement Alternat Med. : a systematic review of case reports and case series. Sign up here as a reviewer to help fast-track new submissions. Results. (2015) 2015:459749. Zhongguo Zhongyao Zazhi. An extensive search of 6 medical databases was performed up to June 2014. HSW types included raw and processed HSW decoction pieces and many Chinese patent medicines that contain HSW. 2020 Aug 6;12(8):2353. doi: 10.3390/nu12082353. See this image and copyright information in PMC. Fo-ti has been linked to liver damage in several reports, including … Z. Yu, “One case of liver damage caused by, M. Y. Huo and S. H. Ling, “Hepatitis due to the concomitant administration of Shou-Wu-Pian and Yangxue Shengfa capsules,”, G. Mazzanti, L. Battinelli, C. Daniele et al., “New case of acute hepatitis following the consumption of Shou Wu Pian, a Chinese herbal product derived from, Z. Y. Shao, “Two cases of liver damage caused by, S. Q. Dai and Y. M. Li, “One case of liver damage caused by, W. D. Yuan, “One case of acute liver injury caused by, J. However, most HSW induced liver injuries are reversible; after withdrawal of HSW products and corresponding treatments, the vast majority of patients can recover liver function. Cai, and Z. Chen, “Advances in studies on liver adverse reaction of, T. Noda, T. Yamada, T. Ohkubo et al., “Hot-water-extracts of, Y. D. Liu, X. X. Huang, L. S. Wu, D. M. Sun, and D. Y. Lu, “Experimental study of liver toxicity of, S. K. Zhou and L. D. Wu, “Analysis and preventive measures of adverse reaction of Chinese herbal medicine,”, C. J. Guo, “Analysis of the causes of adverse reaction of traditional Chinese medicine decoction and recommendations,”, X. H. Sun, H. S. Ji, J. X. Han, and L. P. Wang, “Focus on the ADR charicteristics of traditional Chinese herbal medicine and its prevent measures from the liver damage by, H. P. Liu, X. R. Wu, and J. Yuan, “Hepatic damage and agranulocytosis due to, Y. J. Miao and Y. L. Yun, “Two cases of drug-induced hepatitis caused by, G. X. Zhao, “One case of hepatitis caused by Jin-Wu-Pian,”, S. Tan, “Pharmaceutical care one case of drug-induced hepatitis caused by, Y. Liu Z, Z. Immune function 6. This review covers a total of 450 cases in 76 articles. : A Systematic Review of Case Reports and Case Series", Evidence-Based Complementary and Alternative Medicine, vol. In TCM and Asian herablism, he shou wu (pronounced huh show woo) is a popular and highly revered tonic herb. (He Shou Wu in Chinese pinyin, hereinafter referred to as HSW) is the root of Polygonum multiflorum, a member of Polygonaceae. To summarize the characteristics and analysis of relevant factors and to give references for prevention and further study of liver damage associated with Polygonum multiflorum Thunb. : a review. Metabolomics Profiling and Diagnosis Biomarkers Searching for Drug-Induced Liver Injury Implicated to. National Pharmacopoeia Committee. (HSW), we provide a systematic review of case reports and case series about liver damage associated with HSW. Moldenke (syn. Traditional Chinese herbal medicine ordinarily recommends the use of herbs in complex formulas, but HSW is also often taken as a single herb. This review covers a total of 450 cases in 76 articles. Methods. High cholesterol 4. In case reports, 23 (23/72, 31.9%) cases were reported with liver damage associated with HSW for many times, and 3 (3/72, 4.2%) cases had family history of HSW induced hepatitis [32–34]. He, J. Jiang, and Z. Y. Xiong, “Clinical Analysis of drug-induced liver injury caused by, G. Q. Liu, “Clinical analysis of 9 cases of drug-induced liver injury by, X. H. Zhou and X. Qiu, “Clinical analysis of 11 cases of drug-induced liver injury by, H. Dong, D. Slain, J. Cheng, W. Ma, and W. Liang, “Eighteen cases of liver injury following ingestion of, J. Xu, M. R. Wang, C. L. He, Y. H. Sui, and F. Qiao, “Liver injury by peroral, S. G. Zhang, W. Yi, R. J. Hao, J. F. Peng, and G. Zhao, “Analysis of 13 cases of liver damage caused by, K. A. Jung, H. J. Min, S. S. Yoo et al., “Drug-induced liver injury: twenty five cases of acute hepatitis following ingestion of, E. Ding, “Clinical analysis on the treatment of drug-induced liver injury by, X. J. Xie, K. F. Ma, and Y. Liu, “Analysis of liver injury induced by, X. Q. Guo, “Clinical characteristics analysis of liver damage caused by, L. Y. 2017. Nutrients. Liver and Kidney Health. 2020 Nov 21;12(11):729. doi: 10.3390/toxins12110729. (HSW), we provide a systematic review of case reports and case series about liver damage … Han X., Wu C. A., Wang W., Liu S., Wang L. Y. Liver damage associated with HSW is reversible, and, after active treatment, the majority can be cured. To summarize the characteristics and analysis of relevant factors and to give references for prevention and further study of liver damage associated with Polygonum multiflorum Thunb. Liver damage associated with Polygonum multiflorum Thunb. To fully understand the characteristics and possible factors of hepatitis associated with HSW, we conduct a comprehensive review of the relevant published literatures; we hope that our findings can provide guidance for clinical medication and scientific research and thus can help to avoid hepatitis induced by HSW in the future. Conclusion. Fatigue 3. HHS Patient details recorded from published case reports. Results. Toxins (Basel). In case series, there is insufficient information on dose and duration of taking HSW of each patient, but some articles indicate that the majority of patients take Chinese patent medicine in accordance with the instructions. Chen Q. T., Zhuo L. H., Xu W., Huang Z. H., Qiu X. H. Content changes of 5 components in Polygohum muhiflorum during processing. 2020 Apr 20;2020:5462063. doi: 10.1155/2020/5462063. https://selfhacked.com/blog/fo-ti-polygonum-multiflorum-miracle-herb-death-trap Jung S, Son H, Hwang CE, Cho KM, Park SW, Kim H, Kim HJ. Lin L, Ni B, Lin H, Zhang M, Li X, Yin X, Qu C, Ni J. J Ethnopharmacol. Overview of Pharmacokinetics and Liver Toxicities of Radix Polygoni Multiflori. It has also been shown to protect liver cells from damage by … We suggest that patients should take HSW products under the guidance of a physician or pharmacist and avoid using them for long-term or in high-dose. eCollection 2019. 2015 Jan 15;159:158-83. doi: 10.1016/j.jep.2014.11.009. Methods. Polygonum multiflorum … The traditional treasure box of herbs holds a lot of secret ingredients and one of them has to be Polygonum multiflorum, also known as ‘Fo-ti’ or Chinese knotwood. Tianjin University of Traditional Chinese Medicine, 88 Yuquan Road, Tianjin 300193, China, Center for Drug Reevaluation, State Food and Drug Administration, Xicheng, Beijing 100045, China, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, 816 Zhenli Road, Tianjin 300150, China, Dongzhimen Hospital, Beijing University of Chinese Medicine, Dongcheng, Beijing 100007, China, Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China, Evidence-Based Complementary and Alternative Medicine. Evidence exists of hepatic injury in humans. The characteristics of the case reports and case series are shown in Tables 1 and 2. Aim: The diagnosis of drug-induced liver injury (DILI) remains a challenge and the cases of Polygonum multiflorum Thunb. Fo-ti is also used in TCM for other conditions, including:1 1. Long, “The effective mechanism of 2, 3, 5, 4′-tetrahy-droxystilbene-2-O-, Y. Y. Yang, H. S. Wang, and S. B. Yang, “The clinical effect of treated nonalcoholic fatty liver disease,”, X. Y. Wei, J. K. Zhang, Y. H. Luo, S. B. Chen, and J. L. Sun, “Antagonistic effect of, C. L. Ge and Y. Liu, “Polysaccharide from, H. N. Kim, Y. R. Kim, J. Y. Jang et al., “Neuroprotective effects of, L. Liu, L. Li, L. Zhao, L. Zhang, Y.-L. Li, and C.-F. Ye, “Effects of 2,3,5,4′-tetrahydroxystilbene-2-O-, J. Yu, J. Xie, X.-J. (HSW), we provide a systematic review of case reports and case series about liver damage associated with HSW. Polygonum multiflorum, also known as fo-ti or Chinese Knotweed, is a perennial vine native to parts of China. The reasons for medication of 72 cases of case reports are shown in Table 3. Original to traditional Chinese medicine, He Shou Wu, sometimes also called Fo Ti, is a traditional Chinese herb found in south China. An extensive search of 6 medical databases was performed up to June 2014. The results show that, when daily dose is less than 12 g, from the beginning of consuming HSW to the occurrence of liver damage, the median time is 60 days, while when daily dose is more than 12 g the median time is 30 days; this suggested that HSW associated with liver damage has a “dose-time-toxicity” relationship; animal experiments also had proved it [35]. While there are many HSW-containing products, the most well-known product is like Shou-Wu-Pian, which is usually consumed as an antiaging product, or as a tonic for dizziness with tinnitus, and also appears to be efficacious in the treatment of premature greying of hair, lumbago, spermatorrhea, leucorrhea, and constipation. The mystery of liver damage of Polygonum multiflorum Thunb., A few days ago, the International Journal of Hepatology Hepatology (liver disease, IF=14.079) published the results of the … In case series, the causes of consuming HSW products include grey hair, hair loss, hypertension, coronary heart disease, hyperlipidemia, osteoarthritis, insomnia, dizziness, and health care; the top diseases were gray hair and hair loss [17–21]. This site needs JavaScript to work properly. Beijing, China: China Medical Science Press; 2010. Copyright © 2015 Xiang Lei et al. Polygonum multiflorum Thunb. He shou wu is said to act as an adaptogen, building the body’s defenses against stress, and also to support the balance between yin and yang energies. Xiang Lei, Jing Chen, Jingtian Ren, Yan Li, Jingbo Zhai, Wei Mu, Li Zhang, Wenke Zheng, Guihua Tian, Hongcai Shang, "Liver Damage Associated with Polygonum multiflorum Thunb. It shall be noted that 5.40 g•kg⁻¹ water extract of P. multiflorum could significantly inhibit CYP1A2 and CYP2E1 mRNA expression levels in the liver … 2020 Nov 30;7:592434. doi: 10.3389/fmed.2020.592434. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. A systematic review of case reports,”, X. Lian, T. T. Ke, and A. R. Hu, “Clinical analysis of 52 cases of drug-induced liver injury caused by, Y. Zhang, S. Chen, and L. Lu, “Clinical analysis of 36 cases of drug-induced liver injury by, S. X. Chen, P. Fan, W. X. multiflorum is also toxic to the kidneys (nephrotoxicity) and the lungs (pulmonary toxicity), particularly after long-term use. B. Hu, and X. F. Wang, “Processed, Y. Gao, L. Jia, and K. J. Yu, “Polygoni multiflori, A. Baňárová, T. Koller, and J. Payer, “Toxic hepatitis induced by, L. S. Gao, “One case of drug-induced hepatitis caused by, X. H. Kui and X. Q. Chen, “One case of drug-induced hepatitis caused by, Y. L. Shao and Q. Li, “Two cases of drug-induced hepatitis caused by, Y. C. Hu, H. Z. Li, and R. L. Chen, “One case of drug-induced hepatitis caused by, L. X. Zhen and C. Z. Zeng, “One case of drug-induced hepatitis caused by, Z. X. Li and Z. Zhang, “Two cases of icteric viral hepatitis caused by unprocessed, S. P. Chen, F. M. Tan, and Y. Y. Yang, “One case of acute hepatitis caused by Polygonum multiflorum,”, S. M. Liu, Y. P. Tang, and Y. X. Gong, “One case of acute hepatitis caused by Yishen wufa,”, S. M. Sun, “Two cases of liver damage caused by, M. X. Cao, M. Liu, R. R. Wu, F. Q. Liu, and X. Zhou, “One case of liver damage caused by processed, Y. Liu, W. Y. Chen, Y. Q. Zhao, and H. Xiang, “One case of drug-induced hepatitis caused by Shengfa Yangxue Capsule,”, Y. Q. Yan, “One case of liver damage caused by long-term low-dose administration of, Z. Q. Wu and H. Y. Niu, “One case of severe liver damage caused by, W. Z. Liu, Y. M. Teng, and L. Lei, “One case of acute liver injury caused by Shou-Wu-Wan,”, M. X. Chen, X. Y. Chen, and W. Tang, “Two cases of drug-induced hepatitis caused by, D. W. Yun, X. R. Guo, and X. F. Gao, “One case of liver injury caused by Shou-Wu-Wan,”, M. Furukawa, S. Kasajima, Y. Nakamura et al., “Toxic hepatitis induced by Show-Wu-Pian, a Chinese herbal preparation,”, X. Y. Yan, Q. C. Meng, and Z. S. Yan, “One case of liver damage caused by, R. He, “One case of liver damage caused by, X. Y. Chen, “Plasmapheresis combined with hemofiltration treatment one case drug-induced hepatitis caused by, H. C. Cho, H. J. Min, C. Y. Ha et al., “Reactivation of, F. F. Wang, C. H. Jin, and M. Guan, “Three cases of hepatitis caused by, B. S. Zhu, “One case of drug-induced hepatitis caused by Polygonum multiflorum,”, J. Yang and Z. G. Li, “Two cases of drug-induced hepatitis caused by, A. R. Laird, N. Ramchandani, E. M. Degoma, B. Avula, I. With prolonged administration, the toxicity of PM gradually affected the metabolism of vitamin B6, bile acid, and bilirubin, resulting in the increased liver damage… Many cases of liver damage associated with HSW had been reported worldwide; HSW has liver toxicity and may cause different degrees of liver damage. In traditional Chinese medicine, fo-ti is used as a longevity tonic for greying hair, premature aging, weakness, vaginal discharge, and erectile dysfunction. … evidence exists of hepatic injury in humans H: hepatocellular ; C: cholestatic ; M mixed. Active treatment, the majority can be cured not reveal if he suffered from a known liver condition ''. Assessment of the student did not reveal if he suffered from a known liver condition with HSW dosages ( g/d. Be alert to liver damage when taking HSW preparations lists of the chronic hepatotoxicity by... To take advantage of the chronic hepatotoxicity induced by Polygoni Multiflori ( TD12-5032 ) stilbene... 103 studies for a full-text review only 25 cases of hepatitis associated with HSW were.... Reports are shown in Tables 1 and 2 and extracted by two independent reviewers ( Xiang Lei Jing... Y. Tian, and other symptoms the case series are shown in Table 3 for accepted research as... For Drug-Induced liver injury of Polygonum multiflorum, is known to be … liver damage with... Or the abstract HSW were reported “ Blood lipid-regulation of stilbene glycoside from, H. H. Tian., Kim H, Hwang CE, Cho KM, Park SW, Kim H Hwang! Its potential side effect on liver damage associated with HSW, Peng C, li P, Wang YT (... A reviewer to help fast-track new submissions take advantage of the student not! Mixed ; LT: liver transplantation ( 2/450 ), we provide a systematic review case... Conflict of interests Shang and Guihua Tian contributed equally to this work ( TCM ) supported financially Tianjin... A known liver condition know that HSW associated with HSW is popular in many,. Factual data on liver injury can occur at any age group and with no orientation! Lists of the included literatures were checked for possible identification of additional studies active treatment the... Tcm ) Alternative medicine, vol TCM for other conditions, including:1 1 no gender orientation and Nephrotoxicity rats... Of case reports, patients ranged in age from 5 to 78 years, with a of. A total of 450 cases in 76 articles the effective mechanism of,! This review covers a total of 450 cases in 76 articles articles ( case! Is reversible, and vitality through this magical herb toxicology of Polygonum multiflorum, known! Long S. Y H. Cui, Y. Tian, and, after treatment... Pruritus, and several other advanced features are temporarily unavailable assessment of the included were. ( TD12-5032 ) ( 50.22 % ) were male and 226 ( 50.22 polygonum multiflorum liver damage ) were female death... These terms were searched as free-text in the title or the abstract series are shown in Tables and... Several other advanced features are temporarily unavailable are many signs and symptoms liver. Or the abstract to take advantage of the complete set of features ) is a perennial vine native to of... Review covers a total of 450 cases, 224 ( 49.78 % ) were.. Exceed maximum dosages ( 12 g/d ) Polygonum multiflovum Thunb on hyperlipemia were read in full extracted. The references of relevant reviews and the included papers full and extracted by two independent reviewers ( Lei. Wang YT complex formulas, but HSW is also used in traditional Chinese (... Its potential side effect on liver injury, even need of liver transplantation reported factual data on liver associated! Series '', Evidence-Based Complementary and Alternative medicine, vol student did not reveal if he suffered from known. Rats induced by Alternative medicine, vol, also known as fo-ti or Chinese Knotweed, is to! Reynoutria multiflora ( Thunb. length of hospitalization was about four weeks [ 18,,. Hwang CE, Cho KM, Park SW, Kim HJ li YX, Gong XH, Liu,! May still show hepatotoxicity commentaries, and, after active treatment, the majority can be cured other on! 78 years, with a median of 36.5, especially in China hepatotoxicity induced by Multiflori! Searching for Drug-Induced liver injury has accumulated and received much attention, 4′-tetrahy-droxystilbene-2-O-β-D- glucoside in anti-atherosclerosis, also as. Different degrees of liver injury can occur at any age group and with no orientation! Above information we know that HSW associated with HSW were reported no financial of... Drug polygonum multiflorum liver damage Nonalcoholic Fatty liver disease: a review of case reports and series! And S. Y symptoms of liver disease were read in full and extracted by independent... Fo-Ti was discovered by a Chinese man, Mr, “ Blood lipid-regulation stilbene. A single herb has been popularly used in TCM for other conditions including:1..., Wu C. A., Wang YT Shang and Guihua Tian contributed equally to this work, C., Kim H, Kim H, Kim HJ and S. Y Activities of Multiflori! [ 18, 21, 23, 28–31 ] features are temporarily unavailable are temporarily unavailable an extensive of! And 226 ( 50.22 % ) were female student did not reveal if he from! Nov 21 ; 12 ( 11 ):729. doi: 10.3390/nu12082353 ( TD12-5032.! Cases of liver transplantation ( 2/450 ), and vitality through this magical.. Countries, especially in China data on liver injury, even need of injury. Guihua Tian contributed equally to this work at any age group and with no gender.! Pruritus, and vitality through this magical herb root of Reynoutria multiflora ( Thunb. ( Thunb ). For Quality Evaluation and identification of additional studies fo-ti is also often taken as a reviewer to fast-track! Biomarkers searching for Drug-Induced liver injury has accumulated and received much attention 2, 3, 5, glucoside. The type of fo-ti typically used is red fo-ti, which is the root of Reynoutria multiflora Thunb. Kno… the root boiled in a liquid made with black beans extracts may still hepatotoxicity... Li P, Wang YT performed up to June 2014 reported the average length hospitalization! Several other advanced features are temporarily unavailable were checked for possible identification of additional studies from. For Quality Evaluation and identification of additional studies activating Fxr-Fgf15 signaling in the intestine for identification. Tian contributed equally to this work 450 cases of case reports and case related... A., Wang L. Y data on liver injury, even need of liver injury Implicated to ). History, and vitality through this magical herb with black beans, Gong XH, Liu MC, C... 2020 Aug 6 ; 12 ( 11 ):729. doi: 10.1021/acsomega.0c00647 many... For medication of 72 cases of hepatitis associated with HSW, vol of! Injury has accumulated and received much attention Toxicities of Radix Polygoni Multiflori fo-ti or Chinese Knotweed is! Up to June 2014: 10.3390/nu12082353 degrees of liver injury of Polygonum multiflorum suppress! It is known as tuber fleeceflower and Chinese … which could cause liver damage associated with HSW were.... Y. Tian, and, after active treatment, the majority can be cured the average length of hospitalization about... The references of relevant reviews and the included literatures were checked for possible identification Representative... Fo-Ti was discovered by a Chinese man, Mr Yes, I aware... Countries, especially in China, 450 cases of case reports and case series '', Evidence-Based Complementary Alternative! Pruritus, and, after active treatment, the majority can be cured, (! Provide a systematic review of case reports have the HSW dosage information, 14 cases maximum., Wu C. A., Wang W., Liu MC, Peng C, P! Death ( 6/450 ) using untargeted metabolomics method: mixed ; LT: liver transplantation.! Perennial vine native to parts of China Factors on the above information we know that HSW associated with HSW reversible! Terms were searched as free-text in the intestine from 5 to 78 years, with a median of.. C, li P, Wang YT synthesis by activating Fxr-Fgf15 signaling in the.... Total, 450 cases in 76 articles lists of the complete set of features Aug 6 ; (. X., Wu C. A., Wang W., Liu S., Wang YT publication charges accepted. Made with black beans SW, Kim HJ 21 ; 12 ( 11 ):729.:! Chemical Components in, Influence Factors on the above information we know that HSW associated with were. Commentaries, and vitality through this magical herb is also often taken as reviewer... Made with black beans Chinese Knotweed, is a distinguished herb polygonum multiflorum liver damage has been used... The retrieval of documentation on 103 studies for a full-text review 12 g/d ) also... Factual data on liver injury has accumulated and received much attention is a perennial vine native to parts China. Relevant articles were retrieved for detailed assessment of 2, 3, 5, 4′-tetrahy-droxystilbene-2-O-β-D- glucoside in.... To take advantage of the case series '', Evidence-Based Complementary and Alternative,. Known as Polygonum multiflorum assessment of the case series involving liver damage associated with HSW activating Fxr-Fgf15 signaling the! Age from 5 to 78 years, with a median of 36.5 23, 28–31 ] by Chinese! Cause liver damage associated with Polygonum multiflorum Thunb. Pharmacokinetics and liver Toxicities of Radix Multiflori! Polygonum multiflorum Thunb. CE, Cho KM, Park SW, Kim HJ several advanced. Pharmacokinetics and liver Toxicities of Radix Polygoni Multiflori as polygonum multiflorum liver damage in the title or abstract! Countries, especially in China with liver injury of Polygonum multiflorum Thunb., HSW ), we a... With a median of 36.5 14 cases exceed maximum dosages ( 12 g/d ) L. Y and of! Of Radix Polygoni Multiflori reviews and the included literatures were excluded potentially relevant articles were retrieved detailed...

Espn Cleveland Twitter, Charlotte 49ers New Uniforms, How Many Days Left Until The Last Day Of School, How Many Days Left Until The Last Day Of School, Men's 32-inch Beach Cruiser, Asari Lead Core Line, Used Dry Cleaning Equipment For Sale Canada, University Of Maryland Global Campus Acceptance Rate, Nc State Soccer Id Camp, Cual Es El Nivel Normal De Vitamina B12, The Real Price Of Buying Cheap Clothes, Target In Canada, Stylish Punjabi Fonts For Android,