Caution is advised even when using agents with mild to moderate anticholinergic activity, particularly in elderly patients. High blood pressure (hypertension) and diabetes are the most common causes of kidney disease. Applies to: Ulcerative Colitis. (1979): 501-2, "Lomotil for diarrhea in children." It is a combination of two drugs: belladonna alkaloids and barbiturates. (1972): 336-8, Lowenthal DT, Reidenberg MM "The heart rate response to atropine in uremic patients, obese subjects before and during fasting, and patients with other chronic illnesses." Antimuscarinic agents decrease gastric motility and relax the lower esophageal sphincter which promotes gastric retention and can aggravate reflux. It is also used to control muscle spasms in the bladder, kidneys, or digestive tract, and to reduce stomach acid. Moderate Potential Hazard, Moderate plausibility. May not be suitable for some people including those with heart or lung disease, liver or kidney disease, myasthenia gravis, prostate or thyroid problems, ulcerative colitis or an intestinal obstruction. "Product Information. How should I take hyoscyamine and phenyltoloxamine? medicines that affect the heart's rhythm, such as amiodarone, dofetilide, dronedarone, pimozide, quinidine, sotalol, or procainamide. antacids, such as aluminum hydroxide or magnesium hydroxide, antidepressants, such as amitriptyline, clomipramine, desipramine, doxepin, imipramine, nortriptyline, phenelzine, or tranylcypromine, antihistamines, such as diphenhydramine or promethazine, antipsychotics, such as chlorpromazine, fluphenazine, haloperidol, perphenazine, risperidone, thioridazine, trazodone, trifluoperazine, medicines that affect gastrointestinal motility, such as pramlintide. Applies to: Gastrointestinal Obstruction, Esophageal Obstruction. Medicines that interact with hyoscyamine may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with hyoscyamine. Speak to your doctor about how drug interactions should be managed. Hyoscyamine sulfate passes the blood brain barrier and the placental barrier. These drugs should be administered cautiously to patients with ulcerative colitis. Moderate Potential Hazard, Moderate plausibility. Tavist (clemastine)." (1976): 369-71, Cooper MJ, Abinader EG "Atropine-induced ventricular fibrillation: case report and review of the literature." Hyoscyamine inhibits the action of acetylcholine, the main neurotransmitter of the parasympathetic nervous system. New York, NY: McGraw-Hill Health Professionals Division Applies to: Gastroesophageal Reflux Disease. (1986): 571, Stadnyk AN, Glezos JD "Drug-induced heat stroke." Major Potential Hazard, Moderate plausibility. Curr Med Res Opin 5 Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. (1985): 558-60. Tell your doctor if you are pregnant or breastfeeding. JAMA 241 Effects last for six-to-eight hours (immediate release formulations) or twelve hours (extended-release formulations). (1998): Famewo CE "A re-evaluation of anticholergic premedication." Therapy with atropine-like agents should be administered cautiously to patients with renal disease. Hyoscyamine is used to treat a variety of stomach/intestinal problems such as cramps and irritable bowel syndrome. Hyoscyamine is an anticholinergic drug used for treating irritable bowel syndrome, peptic ulcer disease, hypermotility of the lower urinary tract, and gastrointestinal disorders. It is also used to control muscle spasms in the bladder, kidneys, or digestive tract, and to reduce stomach acid. Blurred vision, constipation, dizziness, drowsiness, dry mouth, flushing, headache, increased sensitivity to light, and problems with urination are the main side effects reported. Hyoscyamine (Levsin) Dose in the treatment of Gastrointestinal disorders: Oral: Tablet, dispersible: Anaspaz, ED-SPAZ, NuLev: 0.125 to 0.25 mg every 4 hours or as needed; maximum: 1.5 mg/day ; Oscimin: 0.125 to 0.25 mg 3 to 4 times daily; may increase to every 4 hours as needed; maximum: 1.5 mg/day; Tablet, extended-release: Levbid: 0.375 to 0.75 mg every 12 hours; maximum: … Applies to: Diarrhea. Kidney disease does not tend to cause symptoms when it's at an early stage. In patients with low urinary output, the salts can precipitate and cause crystalluria. Drowsiness and dry mouth are common side effects. Arch Intern Med 151 Major Potential Hazard, High plausibility. J Allergy Clin Immunol 70 Minor Potential Hazard, Low plausibility. "Product Information. Moderately clinically significant. In general, because antiperistaltic agents decrease gastrointestinal motility, they may delay the excretion of infective gastroenteric organisms or toxins and should be used cautiously in patients with any infectious diarrhea, particularly if accompanied by high fever or pus or blood in the stool. (1992): 564. Moban (molindone)." Be careful in hot or humid climes if taking hyoscyamine as it can decrease your ability to sweat and increase your risk of fever and heat stroke. (1973): 693, Zsigmond EK, Matsuki A, Sharafabadi C "Atropine and cardiac arrhythmia." Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Hyoscyamine is an anticholinergic drug used for treating irritable bowel syndrome, peptic ulcer disease, hypermotility of the lower urinary tract, and gastrointestinal disorders. Anaesthesia 32 Imodium (loperamide)." Acta Anaesthesiol Scand 28 The half-life of hyoscyamine sulfate is 2 to 3 1/2 hours. Dysuria may occur and may require catheterization. For non-prescription products, read the label or package ingredients carefully. Am Heart J 97 It is by slowing down the natural … Premature ventricular depolarization or ventricular tachycardia or fibrillation associated with antimuscarinic drugs is rare. Available for Android and iOS devices. Hyoscyamine sulfate passes the blood brain barrier and the placental barrier. Hyoscyamine is a prescription medication used to used to control symptoms associated with disorders of the gastrointestinal (GI) tract. How it works. CKD can get worse over time and eventually the kidneys may stop working altogether, but this is uncommon. Cogentin (benztropine)." References. Atropine-like agents are primarily eliminated by the kidney. Enchancement of ischemia following intravenously administered atropine." Thyroid levels should be monitored if usage is prolonged. others, such as amantadine, belladonna-containing medicines, macimorelin, or potassium supplements. In addition, this drug is used to lessen the side effects of certain medications and insecticides. Diarrhea may be a symptom of incomplete intestinal obstruction, especially in patients with ileostomy or colostomy. Kidney disease is most often caused by other conditions that put a strain on the kidneys. Do not give this medicine to a child without medical advice. (1979): 1412-4, Schuller DE, Turkewitz D "Adverse effects of antihistamines." diazepam, oxybutynin, dicyclomine, lidocaine, Valium, fentanyl, Amitiza, simethicone, Metamucil, Bentyl. Talk to your doctor urgently if you experience unexplained diarrhea, eye pain, a fast or irregular heartbeat, or develop a skin rash. A drug interaction effect on the gastro-oesophageal sphincter in man." (1983): 957-9, Forester D "Fatal drug-induced heat stroke." (1977): 39-41, Sarnquist F, Larson CP Jr "Drug-induced heat stroke." Janssen Pharmaceutica, Titusville, NJ. Do not give this medicine to a child without medical advice. How does Levsin SL (Hyoscyamine Sulfate) work? Take exactly as directed by your doctor. J Antimicrob Chemother 9 (1982): 209-16 Australian Drug Evaluation Committee "Adverse effects of drugs … ESI Lederle Generics, Philadelphia, PA. "Product Information. In addition to theses, this medicine is considered good for Parkinson’s disease. The basic uses of these two drugs are quite similar. Hyoscyamine may be used in the treatment of a wide variety of gastrointestinal problems including cramps, bladder control issues, and irritable bowel syndrome. Minor Potential Hazard, Moderate plausibility. Ann Ophthalmol 11 These drugs may prolong and/or worsen diarrhea associated with organisms that invade the intestinal mucosa, such as toxigenic E. coli, Salmonella and Shigella, and pseudomembranous colitis due to broad-spectrum antibiotics. Hyoscyamine is used to treat many different stomach and intestinal disorders, including peptic ulcer and irritable bowel syndrome. Poly-Histine-D (pyrilamine)." Pacing Clin Electrophysiol 5 Glaxo Wellcome, Research Triangle Park, NC. "Product Information. Hyoscyamine is used to treat a variety of stomach/intestinal problems such as cramps and irritable bowel syndrome. Muscarinic receptor antagonists reduce bronchial secretions, which can result in decreased fluidity and increased thickening of secretions. Antimuscarinics (Includes hyoscyamine) ↔ coronary artery disease. Hyoscyamine is sometimes used to reduce tremors and rigid muscles in people with symptoms of Parkinson's disease. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. "Product Information. Last updated on Jun 10, 2020. Note that this list is not all-inclusive and includes only common medications that may interact with hyoscyamine. (1973): 348-50, Lee BS "Possibility of hyperpyrexia with antipsychotic and anticholinergic drugs." (1974): 1414-6, Chernish SM, Brunelle RR, Rosenak BD, Ahmadzai S "Comparison of the effects of glucagon and atropine sulfate on gastric emptying." Applies to: Autonomic Neuropathy. Usually avoid combinations; use it only under special circumstances. Relieves spasms or cramping and controls excessive bronchial, pharyngeal, stomach, and tracheal secretions. Applies to: Arrhythmias, Ischemic Heart Disease . Orap Tablets (pimozide)." INDICATIONS AND USAGE Hyoscyamine sulfate is effective as adjunctive therapy in the treatment of peptic ulcer. SmithKline Beecham, Philadelphia, PA. O'Connor PS, Mumma JV "Atropine toxicity." Section II: Anticholinergic drugs." Tell your doctor if you are pregnant or breastfeeding. Can Med Assoc J 128 Obstet Gynecol 51 We comply with the HONcode standard for trustworthy health information -, https://www.drugs.com/ppa/hyoscyamine.html, Drug class: anticholinergics/antispasmodics, Hyoscyamine Orally Disintegrating Tablets. (1983): 92-4, Clearkin LG "Angle closure glaucoma precipitated by atropine." Ann Ophthalmol 6 Merck & Co, Inc, West Point, PA. "Product Information. (1985): 613-4, Berdy GJ, Berdy SS, Odin LS, Hirst LW "Angle closure glaucoma precipitated by aerosolized atropine."
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